April 1 - The Sea Beggars, Netherlandish Calvinist rebels, capture the port city of Brielle. This leads to a wave of uprisings in Holland and Zealand, leaving most of those provinces (with the exception of Amsterdam, under rebel control.
August 24 - St. Bartholomew's Day Massacre in Paris. Catholics in Paris murder thousands of Protestants, including Gaspard de Coligny, at the order of King Charles IX. Henry of Navarre and the Prince of Condé barely escape the same fate. This brings about the Fourth War of Religion in France.