Born in Avignon, France. He entered the novitiate of the Society of Jesus at Rome on April 24, 1612.

Quốc Ngữ, an alphabet based on the Roman character set, which is used today to write the Vietnamese language was introduced by Alexandre de Rhodes.

Alexandre de Rhodes died in Ispahan, Persia.

In 1943, the French colony of Indo-China issued a 30c postage stamp honoring him.