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The film deals with complex issues such as AIDS, transvestitism, sexual identity, religion, faith, and existentialism; the characters are presented in a straightforward and mostly unromanticized and non-judgemental fashion but with an edge of dark humour. The film won an Academy Award for Best Foreign Language Film in 2000.
The title is a play on the film title All About Eve, of which Esteban is a fan, he complains that the translation of the title into Spanish is a poor one, and should have been "Todo sobre Eva."
One night after watching a play of Tennessee Williams' A Streetcar Named Desire Esteban is running after an actress to get an autograph when he is hit by a car and dies. Manuela sees the accident and leaves Madrid to visit her son's father, Lola, who is now a transvestite in Barcelona. While in Barcelona, Manuela befriends another transvestite (named Agrado), a nun, and the actress that his son admired.