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His most famous paintings included Alexander weilding a thunderbolt, Aphrodite Anadyomene, showing the goddess rising from the sea, and a portrait of Antigonus I Monophthalmus on horseback. None of his work survives.
Such was Apelles' fame that several Renaissance painters modelled themselves on him. Raphael may have portrayed himself as Apelles in the School of Athens and Sandro Botticelli based two paintings, The birth of Venus and Calumny of Apelles, on his works.