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In Atlanta, John Pemberton, a pharmacist, developed his own cocktail based on Vin Mariani. It proved popular among American consumers. But in 1886, when Georgia introduced Prohibition, he had to replace the wine in his recipe with non-alcoholic syrup. The new recipe was the origin of Coca-cola.
At the end of the 19th century, the fear of drug abuse made coca-based drinks less popular. This eventually led to the outlawing of cocaine in the United States.