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He came back as head of the company after he found retirement did not suit him. Thomas started out in business by purchasing four Kentucky Fried Chicken franchises, and was strongly influenced by KFC founder Harlan Sanders. He later sold his KFC franchises and opened his first Wendy's in Columbus, Ohio, in 1969. At the time of his death, there were onver 6000 Wendy's restaurants operating in North America.
Adopted as an infant, Thomas was himself a well-known advocate for adoption, founding the Dave Thomas Foundation for Adoption in 1992. Having dropped out of high school at age 15, he finally got his GED in 1993. Thomas died in 2002 at his home in Fort Lauderdale, Florida after a decade-long struggle with liver cancer.