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When used as a drug, DPT is a very powerful psychedelic entheogen, with onset in minutes and a duration of less than 4 hours. DPT is metabolized by the enzyme monoamine oxidase and is not often taken orally unless combined with a monoamine oxidase inhibitor (MAOI), which increases the length and intensity of the experience.
DPT is used as a religious sacrament by the Temple of the True Inner Light, a New York City offshoot of the Native American Church. The Temple believes that DPT and other entheogens are a physical manifestation of God.
Similar compounds to DPT known to have psychoactive effects are DET (N,N-diethyltryptamine), DMT (N,N-dimethyltryptamine), 5-MeO-DMT (5-Methoxy-N,N-dimethyltryptamine) and others. These produce similar yet substantially different effects than DPT.