Pitching for the Los Angeles Dodgers, he teamed with Sandy Koufax during the 1960s to form one of the most dominating pitching duos in history. The ferocious hurler used brushback pitches and a sidearm fastball to intimidate batters, and his 154 hit batsmen remain a modern National League record.

In 1962, Drysdale won 25 games and the Cy Young Award, and set a record with 58 consecutive scoreless innings in 1968. In 1965, the all-around athlete was the Dodgers' only .300 hitter and tied his own National League record for pitchers with seven home runs. He was later inducted into the Baseball Hall of Fame in 1984.

Don Drysdale retired after the 1969 season and became a broadcaster for the Dodgers. He died of a heart attack in his hotel room in Montreal, Canada where he had been broadcasting a game in 1993.

He is interred in Forest Lawn Memorial Park Cemetery, in Glendale, California.