Enedwaith (Sindarin] for 'Middle Region') is located in Eriador, a name for all the lands between the Misty Mountains and the Ered Luin.

The northern border of Enedwaith is the river Gwathló, north of which lies Minhiriath. In the north-east, Enedwaith is bordered by the river Glanduin, across which lay the Noldorin realm of Eregion or Hollin in the Second Age.

The southern border is not exactly clear, but is probably formed by the river Isen. The area of land beyond the Isen is not named. In the west it is bounded by the Great Sea or Belegaer.

Enedwaith formed the most northern part of the Kingdom of Gondor, at least officially, but by the late Third Age it had been abandoned. The city of Tharbad, built at the point where the Glanduin met the Gwathló, was abandoned and ruined after the Great Plague. The land was further ruined by devastating floods in 2912 T.A..

During the First and Second Age Enedwaith was very forested, but as the Númenóreans needed more and more wood for their ships they began to cut down these forests, and built an outpost on the Gwathló, Lond Daer or Lond Daer Enedh, Great (Middle) Haven.

The inhabitants of Enedwaith, distant relations to the Haladin of old, were angered by this. They rebelled against the Númenóreans, and were persecuted. Because the Enedwaithrim spoke a different language than the Númenóreans, they were not seen as relations, and not classified as Middle Men.