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The story begins with brothers Seth Gecko (Clooney) and Richard Gecko (Tarantino) on the run from the law. Headed to Mexico, they encounter the Fuller family, whom they take hostage, and then make their way across the border.
In Mexico, they must meet a contact, Carlos (Marin) at a bar called the "Titty Twister". Carlos will meet the brothers there just before dawn. However, once inside, the Gecko brothers and their hostages, the Fuller family, must work together to survive...