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Gensomaden Saiyuki deals with the fortunes of four fighters - the monk Genjo Sanzo, the monkey deity Son Goku, the half-demon Sha Gojyo, and the demon Cho Hakkai, who have been dispatched by the gods to India to investigate a process that seems to be turning all demons insane. Demons, who have formerly coexisted peacefully with humans in Shangri-La, are going berserk and turning against them.