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It drains an area of 5572 square miles (14,431 km2). The Grand River carries an average 3800 cubic feet per second. It has several dams along its length but is a trout and salmon stream for much of its length.
It is estimated that 22% of the pesticide usage in the Lake Michigan watershed occurs in the Grand River drainage which accounts for only 13% of the total watershed. Much of the basin is flat and it contains many swamps and lakes; although, there is an elevation difference of 700 feet between the source and mouth of the river.
Tributaries are the Red Cedar River, Looking Glass River, Maple River, Flat River, Thornapple River, and the Rogue River.
A 500 passenger dinner cruise ship modeled after a riverboat operates on the river in Lansing.