On February 14, 1981, in Luxembourg, he married Maria Teresa Mestre (born March 22, 1956 in Havana, Cuba, the daughter of Don José Antonio Mestre y Alzarez-Tabio and his wife, formerly María Teresa Batista y Falla).

Their children are:

1. Hereditary Grand Duke Guillaume (1981-)
2. Prince Félix (1984-)
3. Prince Louis (1986-)
4. Princess Alexandra (1991-)
5. Prince Sébastien (1992-)

See also: Grand Ducal Family of Luxembourg