The airport is hub to Continental Airlines and has the IATA Airport Code CLE.

Here are a list of airlines that fly to Hopkins International:

• Air Canada Jazz
• American Airlines
• American Eagle
• American Trans Air
• Atlantic Coast Airlines dba United Express
• Atlantic Southeast Airlines dba Delta Connection
• Comair dba Delta Connection
• Commutair dba Continental Connection
• Continental Airlines
• Continental Express
• Delta Air Lines
• Mesaba Aviation dba Northwest Airlink
• Northwest Airlines
• Pinnacle Airlines dba Northwest Airlink
• Southwest Airlines
• United Airlines
• US Airways