It has twice been filmed, though the films are generally regarded by critics as having been very poor adaptations:

• 1964: The Last Man on Earth (Italian film, original 1963 title L'Ultimo Uomo Della Terra) Matheson wrote the screenplay for this adaptation, but it was so changed in later rewrites that he did not want his name in the credits, and is listed there under the pseudonym "Logan Swanson". The film starred Vincent Price
• 1971: The Omega Man, starring Charlton Heston and Anthony Zerbe, Matheson had no influence on the screenplay for this film.

• 2002: 28 Days Later, by Trainspotting (movie) director Danny Boyle. Arguably an adaptation of the book, that replaced vampires with murderous zombies.