KMOX was organized in 1925. The call letters KMOX don't stand for anything, but in the station's first broadcast, the mayor of Kirkwood, Missouri, where the station's transmitter was located, called the station "St. Louis' Xmas Gift to the World". In 1927, it was one of the sixteen original stations in the CBS network. CBS eventually bought KMOX.

A list of notable broacasters who worked at KMOX: