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Monk was originally a detective of the San Francisco Police Department. After the murder of his wife, a case which he could not solve, Monk became obsessive compulsive, refusing to leave his house for 3 years. Monk's personal nurse, Sharona Fleming (Bitty Schram), helped get Adrian back on his feet.
Eventually, Monk started his own private detective agency, helping the police solve difficult cases. Police captain Leland Stottlemeyer (Ted Levine) and Lieutenant Randall Disher (Jason Gray-Stanford) call on and spar with Monk when they have a case they can't crack.