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Jamie was born to a family living near the Los Alamos research facility; the background radiation may have induced his mutation. When Jamie was born, the doctor’s slap caused him to multiply into two identical babies, which was rather a surprise to his parents and the doctor. Professor Charles Xavier suggested that the Madroxes move to Kansas and raise the boy in privacy. His father created a suit for him to wear which would absorb kinetic energy, the presumed source of the duplication. When Jamie was 15, his parents were killed by a tornado, and for the next few years he ran the farm by himself until his suit one day malfunctioned. He ran for help to New York City, where he met Mister Fantastic of the Fantastic Four. Mister Fantastic helped him with the suit and informed Professor Xavier of the dilemma.
Jamie was invited to join the X Men, but he declined. Instead, he moved to Muir Island to assist Dr. Moira MacTaggert with her research. He was a member of X Factor when the group was under Val Cooper's control. However, during a battle with the would-be savior Haven, Madrox was apparently killed as a result of a disease he had contracted. Unknown to all, a duplicate had died; the real Madrox lived, amnesiac. Although he did not rejoin X-Factor, he did regain his memnory and returned to the superheroic life.