Orvieto is noted for its Romanesque-Gothic cathedral, designed by Arnolfo di Cambio, with construction beginning in 1290. Inside the cathedral is Luca Signorelli's masterpiece, his fresco of the Last Judgment (1499).

Orvieto is home to Etruscan ruins and the remnants of a wall that surrounded the old city more than 2000 years ago. Surrounded by peach and apple trees, and vineyard, there are underground tombs were the Etruscans buried their dead, in stone chambers.