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He married Anne Digby (died 1715), daughter of the 2nd Earl of Bristol on June 10, 1665. His second son Charles succeeded him as the 3rd Earl of Sunderland.
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|width="30%" align="center"|Preceded by:
Henry Spencer
|width="40%" align="center"|Earl of Sunderland
|width="30%" align="center"|Followed by:
Charles Spencer
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