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In 1997 she made her feature film debut, in Under the Skin. By 1998, she had received a nomination for the Academy Award for Best Supporting Actress, for Woody Allen's Sweet and Lowdown. In 2004, she received a nomination for the Academy Award for Best Actress for In America. Although not nominated for an Oscar, she received critical acclaim for her performance in Minority Report.
She has a daughter, Esme, with actor Charlie Creed-Miles.