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San (or santo) is the Spanish word for saint, as in San Francisco (Saint Francis) and San Diego. San is used as a title only, whereas santo is the regular usage (as in «él es un santo» or "he is a saint") or a title (as in Santo Domingo).
San is also the name of an ethnic group who live in South Africa and Botswana.
A SAN is a Storage Area Network in computing.
San is the fictional girl raised by a wolf goddess in Miyazaki Hayao's animated movie Princess Mononoke - the movie's title is a name by which she is also known.