SPC is a TLA that may stand for:

• St. Paul's College (spc.edu.hk)
• Secretariat of the Pacific Community (spc.int)
• Saint Peter's College (spc.edu)
• St. Petersburg College
• St. Philip's College
• Saturn Performance Club
• Science Policy Committee (FASEB)
• Security in Pervasive Computing
• Self-Propelled City
• Serum protein concentrate
• Sociedade Portuguesa de Cardiologia (spc.pt)
• Society of Pension Consultants (spc.uk.com)
• Software Productivity Center Inc. (spc.ca)
• Software Productivity Consortium
• Solution Partnership Center (IBM)
• South Plains College
• Southwest Preparatory Conference
• Soy protein concentrate
• State Property Committee (Mongolia, spc.gov.mn)
• Statistical process control
• Statistic Process Controls Inc.
• Storage Performance Council
• Storm Prediction Center (US NOAA)
• System Planning Corporation