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Most of Srem is located in northern Serbia and Montenegro in what is known as the Vojvodina. Major cities include Sremska Mitrovica, Zemun, Šid, Ruma, Inđija.
The western parts of Srem/Srijem are in easternmost Croatia, though the border between this region and Slavonia to the west is unclear. It runs somewhere along the line Vukovar-Vinkovci-Županja and is thus restricted to the Vukovar-Srijem county.