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In 1784 Wesley appointed him to be 'Superintendent' of American Methodism and during his first trip to the United States later that year Coke ordained Francis Asbury to be his colleague. A modern day printing company for the United Methodist, Episcopal, Presbyterian Churches as well as Disciples of Christ was created combining the surnames of Francis Asbury and Thomas Coke to make Cokesbury (the official printing company for the listed denominations.
Coke was to make repeated visits to the United States during the next twenty-five years. He travelled extensively on preaching tours and, while he was never fully accepted because of what Americans viewed as his divided loyalties, he nevertheless played a significant part in shaping the American Church.
Coke served two terms as President of the Wesleyan Conference and also presided regularly over the Irish Conference. His most significant contribution was however in the field of overseas missions. In addition to his work in the United States, he made four tours of the West Indies and promoted missionary ventures in Canada, West Africa and Gibraltar. Coke died while en route to [[India] as the leader of the first Methodist mission to that country.