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They were the oldest and one of the most civilized Turkish-speaking peoples living in Central Asia. Renowned as Huihe (回紇 hui2 he2) in Chinese sources, they established a khanate in the 8th century while taking over the power vacuum left by the Gokturks. Huihe and Uighurs are in fact represented as the same ethnic group by their close pronunciation and numerous anthropological evidences.
They belonged to the Juan Juan from 460-545, and then to the Hephthalites from 541-565 before being taken over by the Gokturk Khaganate.
They eventually gained a significant dominance over both China and other Turkic tribes. Eventually overrun by Kirghiz and Mongol armies, they lost their independence around the end of the 12th century and were annexed by several states, the most recent of which is China.
Since the 10th century, Uighurs are typically Muslims. Before Islam, Uighurs were Manicheans or Buddhists, and were, in fact, not quite Uighur. Today's Uighurs descend from the Turkic tribe as well as the pre-Turkic Indo-European-speaking Tocharians (or Tokharians). Today, one can still see light-skinned, -haired, and -eyed citizenry belonging the Uighur ethnic group.
Famous Uighurs include Wu'er kaixi.
See also: Uighur language, East Turkestan, Uighurstan, Kushan