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Urease
Urease
is an
enzyme
that
catalyzes
the
hydrolysis
of
urea
into
carbon dioxide
and
ammonia
. The reaction occurs as follows:
(NH
2
)
2
CO + 3H
2
O → CO
2
+ 2NH
4
OH
In
1926
James Sumner shows that urease is a
protein
. Urease is found in
bacteria
,
yeast
and several higher
plants
.
Characteristics:
Molecular weight
: 480
kDa
Optimum
pH
: 7.4
Enzymatic specificity : urea and hydroxyurea
Inhibitors :
heavy metals
,
sodium
,
potassium
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